Remarkable immune specificity and memory, which are properties of theī and T cells owing to an extreme diversity of their antigen receptors. Jawed vertebrate species from fishes to humans. Gnathostomata) more than 450 million years ago and is found in all extant The adaptive immune response was acquired by jawed vertebrates (or Immune responses to be managed in genomic databases and tools. This major breakthroughĪllowed genes and data of the complex and highly diversified adaptive Immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V),ĭiversity (D), joining (J) and constant (C) genes were officially recognizedĪs “genes” as well as the conventional genes. Interface between immunogenetics and bioinformatics. The advent of immunoinformatics, a new science, which emerged at the , was created in 1989 by Marie-Paule Lefranc at Montpellier, France IMGT ®, the international ImMunoGeneTics information system ® IMGT unique numbering Next generation sequencing IMGT Immunogenetics Immunoinformatics IMGT-ONTOLOGY Immunoglobulin (IG) T cell receptor (TR) Immune repertoire High-quality results contribute to the large scale vision of antigen receptor repertoires and understanding of the adaptive immune responses (protective in vaccination, cancer and infections and pathogenic in autoimmunity) for diagnosis, prognosis and therapy. IMGT/HighV-QUEST, the high throughput version of IMGT/V-QUEST and IMGT/Junction Analysis, created in 2010, is the first and, so far, the only online portal for analysis of the immunoglobulin and T cell receptor repertoires obtained from next generation sequencing. IMGT ® comprises seven databases, 15,000 pages of web resources and 17 tools, and includes data from fishes to humans, for basic to veterinary, medical and translational research. The concepts include the IMGT ® standardized keywords (identification), IMGT ® standardized labels (description), IMGT ® standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT ® has been built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and three-dimensional structures. IMGT ® is specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility proteins of humans and other vertebrate species, and in the proteins of the immunoglobulin superfamily and major histocompatibility superfamily of any species. Which emerged at the interface between immunogenetics and bioinformatics. By its creation in 1989, IMGT ® marked the advent of immunoinformatics, The global reference in immunogenetics and immunoinformatics. IMGT ®, the international ImMunoGeneTics information system ® (Centre National de la Recherche Scientifique and Montpellier University) is The high throughput analysis resulting from the next generation sequencing technologies offers an invaluable large scaleĬharacterization of the expressed repertoires and, consequently, a better understanding of the protective and pathogenic immune responses. Natural huge diversity of the antigen receptors that are the immunoglobulins or antibodies and T cell receptors, expressed by B cells and TĬells, respectively. The analysis of adaptive immune repertoires in autoimmune and infectious diseases represents a fascinating challenge because of the

Tcr repertoire imgt